
House holiday rentals in La Mesa
Find and book unique houses on Airbnb
Top-rated house rentals in La Mesa
Guests agree: these houses are highly rated for location, cleanliness and more.
Holiday rentals for every style
Get the amount of space that is right for you
Popular amenities for house rentals in La Mesa
House rentals with a pool

3 BR Urban Oasis with Pool and Spa in Great Area
Loved everything about our stay at this amazing house! Comfortable beds, awesome backyard with pool and hot tub, great location- walking distance to restaurants, coffee shops, park and very close to lots of site seeing. Our family of 5 had a wonderful time - thank you for sharing your lovely house with us!

Private 3 bedroom block to Bay New Pool Spa, Bikes
great location and amenities - we really appreciated the garage parking spot as it's in a popular beach area. Easy access to the beach boardwalk, and the house has a nice saltwater pool and spa with all the floaties and life jackets for the kids. We found everything we needed to have a fantastic spring break!

Fletcher Hills luxury, Sunset View, 4 BR, Pool/Spa
A Perfect Getaway in El Cajon! From the moment we arrived, this stunning Airbnb exceeded all expectations. Nestled in the scenic hills of El Cajon, the property is peaceful, beautifully maintained, and feels like a true retreat. The home itself is immaculate—thoughtfully decorated with a blend of modern touches and cozy charm. Every detail, from the plush linens to the fully stocked kitchen, made us feel pampered and at home. Waking up to the golden California sun streaming through the windows and enjoying coffee on the patio with panoramic views was a daily highlight. The outdoor space is a dream—lush landscaping, a relaxing seating area, and the kind of quiet that lets you truly unwind. Our host was incredibly welcoming and responsive. Whether you’re looking to explore San Diego or just relax in a serene setting, this is the perfect place. We left feeling refreshed, grateful, and already planning our next trip!

Lionhead - Private Boutique Home
My family and I enjoyed our stay. The host was responsive to any questions we had. The home was clean and accommodating. There were great features in the home including generous offerings of subscription services such as TV, music and video games. The host is also generous with pool and hot tub heating at our discretion and leisure up until quiet hours. The pool and hot tub and cabana were clean and made our stay very fun. Another great feature of this home is the overall vibe and vinyl records and whole house Sonos. The home is nicely equipped with lots of towels, full kitchen, games, and even a puzzle with all the pieces! The home is private. We were also able to walk to restaurants and coffee shops. Overall we thoroughly enjoyed our stay and would stay at this location again and plan to look at other options offered by this host.

Centrally located Home w/Guest House, Pool & Spa!
We had a great stay over spring break! Our group was 5 adults & 4 children, but we never felt cramped! The neighborhood is charming and felt safe, even to this small town family. We walked into the Kensington main street area most days - for coffee (Starbucks), acai bowls & organic groceries (Stehly Farms Market), pizza, burgers (kids eat free on Tuesday!), and ice cream (you MUST try the Ube & Toffee flavor at Stella Jeans)! :) The kids loved the pool/ hot tub, although it was a shame the pool guy never checked in over our weeklong stay. With 4 children in the pool every day, the water was cloudy by the time we left. I blame myself for not letting Zeina and Mo know, as they were responsive for all my other queries. The casita was a blessing for grandma and grandpa, who needed their quiet time. The only real complaint I heard from our group was that the house smells stale (like the charming old house it is) and the laundry/pingpong area smells of mildew. Opening doors helped!

Bright and spacious home with views, pool & spa.
Beautiful home. Great host. Would highly recommend.

University Heights Oasis Getaway
There are simply not enough stars to rate this exceptional home! This mid-century modern home was impeccable — interior design was gorgeous, exterior was serene and flowed with the open living. The pool was well maintained and every detail to make guests comfortable were taken. We loved our time there! I can’t thank you enough Lacee for making our trip truly wonderful. We hope to come back soon!

5BR | Salt Water Pool | Hot Tub | Fire Pit| BBQ
The home was beautiful. It was a great please for a family of 8. Great location to relax at home and to get out and enjoy San Diego. The host was very responsive and would stay again.
Weekly house rentals

Bay View Beach House - Coastal Retreat
Michael was a great host. I really appreciated the opportunity to check in early even though it didn’t work out. I also appreciated the fast and efficient communication. The house was perfect for our stay. Would definitely recommend. Thanks again for your hospitality!

Clean 1BR/1BA Guest House Peaceful Private Casita
This spot is so cozy and quiet. Very convenient for visiting SDSU and other local attractions. I also appreciated being able to park behind the gate in the driveway instead of street parking.

𖤓 OB Tropics - 2 Br Close to all the Action!
My family of 4 stayed here for a week and had a wonderful time! The house was comfortable with a beautiful outdoor area and comfortable interior with everything we needed. The host was extremely responsive and friendly. We would definitely stay here again!

Mission Beach House with a rooftop deck
This place is amazing! The location is priceless. It’s steps to the beach and literally next to the restaurants, breakfast/lunch cafe across the street. Would definitely stay there again!

San Diego Bay Home - 3Bd/1.5Bth/Driveway/Yard-Deck
We had a great stay. The host was very friendly and accommodating. Thanks!

☀️ Sunny Cottage-Walk to Beach+Private Yard/Patio
We had a wonderful stay! It was the perfect San Diego home base for a weekend getaway. Really convenient to everything and tucked away so quiet and peaceful in the evenings. Thanks for a great stay!

BohoModrn 4Br/2Ba, 20mins Beach, DT, SeaWorld
Marjorie and Dan’s home was vey nice, clean and bright. We felt very comfortable there. Hosts were very responsive and friendly. We would definitely stay there again.

Exclusive Mission Hills: Views, Breezes & Sunsets
Jaime’s house exceeded our expectations. The location was stunning and the house was spacious and had everything we needed. We are a family of five, and it was nice to be able to spread out, relax and enjoy a space that felt like home. We did not have a car but found the location was fairly close to most San Diego attractions. It is a short walk down to Old Town which has lots of eateries and the transit station, where you can catch the trolley and buses. We used Uber too. Jaime provided lots of great ideas for places to go and was friendly, prompt and easy to communicate with.
Private house rentals

Impeccable & private: cozy KING BEDS, sweet Patio
2nd stay at this home. We absolutely love the team and the homes they offer. If you’re anywhere in the San Diego area this is where you start.

Cozy Private Home in South Bay, San Diego
The Airbnb was so charming, great, quiet neighborhood. We had a Muay Thai tournament 5 minutes away, it was a perfect location and everything we needed, food and stores were 5 minutes away.

Fully Renovated Beach Cottage - 2 blocks beach
Doug's place was perfect for a our family of 4! Great location in OB. would highly recommend this place for families

Pacific Beach Bungalow - Steps from Mission Bay!
Erik's place was the ideal space for my husband, daughter and me for a quick weekend trip to San Diego. Loved that parking was included and that we could easily walk and get coffee and other meals just a few doors down from the rental. We were in town for a regatta at Crown Point Park, so this location was ideal as it was just a five minute walk to the park. The rental was clean and roomy!

Bay Ho Main house
We rented this for my sister’s bachelorette and it was PERFECT! It was decorated very beautifully and was clean!

🏠LuxuryHome in Chula Vista Luxurious neighborhood
I love that the host was very helpful and responsive everytime I had a question or concern . They also let the house very clean and it felt like home . Thanks for allowing me to enjoy my birthday weekend at your residence .

House, 2 bedroom, 2 bathroom
This location is ideal for quick pickups and is conveniently close to popular tourist spots. A vehicle is recommended for easy access. The presence of fruit trees adds a delightful touch, making it a very sweet and appealing place to stay. Will stay here again!

The Turf in Del Mar
We have stayed here before, and the location could not be more perfect- it is so close to the beach and walkable to a dozen restaurants. The house is stocked with everything you need to cook to be at the beach (chairs, boogie boards, sand toys, etc) and is very comfortable for a family! Highly recommend.
Quick stats about house rentals in La Mesa
Total rentals
290 properties
Total number of reviews
12K reviews
Family-friendly rentals
180 properties are a good fit for families
Pet-friendly rentals
90 properties allow pets
Rentals with a pool
70 properties have a pool
Rentals with dedicated workspaces
170 properties have a dedicated workspace
Destinations to explore
- San Diego Holiday rentals
- La Joya Holiday rentals
- Palm Springs Holiday rentals
- Anaheim Holiday rentals
- Stanton Holiday rentals
- Joshua Tree Holiday rentals
- Los Angeles Holiday rentals
- Santa Monica Holiday rentals
- San Fernando Valley Holiday rentals
- Channel Islands of California Holiday rentals
- Southern California Holiday rentals
- Las Vegas Strip Holiday rentals
- Rentals with a fireplace La Mesa
- Guest house rentals La Mesa
- Family-friendly rentals La Mesa
- Rentals with an EV charger La Mesa
- Rentals with pools La Mesa
- Pet-friendly rentals La Mesa
- Private suite rentals La Mesa
- Rentals with beach access La Mesa
- Rentals with a washing machine and dryer La Mesa
- Family-friendly rentals La Mesa
- Rentals with a patio La Mesa
- Fitness-friendly rentals La Mesa
- Rentals with a hot tub La Mesa
- Rentals with a beach view La Mesa
- Rentals with breakfast La Mesa
- Flat rentals La Mesa
- Smoking-friendly rentals La Mesa
- Rentals with a firepit La Mesa
- Rentals with outdoor seating La Mesa
- House rentals San Diego County
- House rentals California
- House rentals United States
- Yurt Rentals United States
- Yurt Rentals United Kingdom
- Castle Rentals United States
- Houseboats United States
- Holiday Caravans United Kingdom
- Private Island Rentals United States
- Farm Houses United States
- Farm Cottages United Kingdom
- Cabin Rentals Australia
- Luxury Cabins United Kingdom
- Luxury Cabins United States
- Holiday Chalets United Kingdom
- Cottage Rentals United States
- Holiday Cottages United Kingdom
- Mansion Rentals United States
- Villa Rentals United Kingdom
- Holiday Bungalows United Kingdom
- Bungalow Rentals United States
- Condo Rentals United States
- Holiday Apartments Australia
- Holiday Houses United States
- Holiday Houses United Kingdom
- Private Holiday Rentals United Kingdom
- Big House Rentals United States
- Big Cottages Australia
- Large Villas United Kingdom
- House Rentals with a Pool United States
- Cabin Rentals with a Pool United States
- Villas with a Pool United Kingdom
- Apartments with a Hot Tub United States
- Holiday Cottages with a Hot Tub United Kingdom
- Beach Cabins United States
- Beach Condos United States
- Beachfront Rentals United States
- Beach Houses United Kingdom
- Beach Villas United Kingdom
- Coastal Cottages United Kingdom
- Pet-Friendly Vacation Rentals United States
- Pet-Friendly Beach Rentals United States
- Pet-Friendly Cabin Rentals United States
- Dog-Friendly Cottages United Kingdom
- Luxury Dog-Friendly Cottages United Kingdom
- Windansea Beach
- SeaWorld San Diego
- University of California San Diego
- Santa Monica Beach
- Playas Los Buenos
- San Diego Zoo Safari Park
- LEGOLAND California
- Balboa Park
- Pechanga Resort Casino
- Belmont Park
- Liberty Station
- Sesame Place San Diego
- Moonlight Beach
- Playa Popotla
- Silver Strand State Beach
- South Mission Beach, San Diego
- USS Midway Museum
- Hillcrest
- Law Street Beach
- Temecula Creek Inn
- Aviara Golf Club
- Buccaneer Beach
- Torrey Pines Golf Course
- Swami's Beach