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Guest house holiday rentals in Panama

Find and book unique guest house rentals on Airbnb

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Popular amenities for guest house rentals in Panama

Family-friendly guest house rentals

Top guest favourite
Guest house in Nueva Gorgona
4.99 out of 5 average rating, 71 reviews

Beautiful Casita-Paradise in Panama, New Gorgona

Mendee And AndresRating, 5 stars1 month ago
We absolutely LOVED our stay at Linda and Russ’s beautiful piece of paradise. Everything was just perfect! The house is darling, super comfortable, everything you could possibly need for a fully functional kitchen (scissors!), a nice big king-size bed. The grounds are AMAZING! We took advantage daily of their big, clean swimming pool. Linda and Russ are exceptional hosts! They are friendly, full of information but also give you lots of space and respect your privacy. There was nothing, I mean nothing that they didn’t think of that would make your stay perfect. There was thought put into every single detail. And Emma… oh sweet little Emma… the neighbor’s visiting cat that makes sure you get your daily dose of love. Please tell little Emma how much we miss her.
Guest house in Bocas del Toro Province
5 out of 5 average rating, 4 reviews

Las Palmas Casita at Bluff Beach Retreat

MarcRating, 5 stars25 months ago
We really enjoyed our vacation, and we can definitely renommend Bluff Beach Retreat. Karen and Steve were very helpful and took good care of us. The nature and the beautiful sorroundings were amazing. A boat trip with Luis, arranged by Karen, is something you shouldn’t miss out - a fantastic guy:)
Guest house in Coloncito
4.95 out of 5 average rating, 19 reviews

Beautiful Casita-Paradise in Panama, Nueva Gorgona

Dustin And GingerRating, 5 stars18 months ago
Love this place! Comfortable and close to everything. Russ and Linda are great to work with. We will be back!
Guest house in Jaramillo Arriba
4.92 out of 5 average rating, 38 reviews

Casita Caramelo

DavidRating, 5 stars14 months ago
A quiet apartment surrounded by a beautiful garden. The home was very clean, and we felt at home right away. Our host Pam was very welcoming to us. I cook and whatever I reached for, Pam had provided. No scratch teflon, a good set of knives and a sharpener, plenty of dishes and glassware, the list goes on. She was particularly considerate to our privacy (for example, by calling us when she’d have to be behind the house to refill a gas canister) but was always responsive when we’d reach out. And she’s a lovely friendly person too.
Top guest favourite
Guest house in Panamá
4.93 out of 5 average rating, 43 reviews

Private cabin and CasaMomote river, Loma Limón.

JosuRating, 5 stars3 days ago
Excellent stay, from the first moment Mariel made us feel at home with her kindness and generosity. The environment, surrounded by nature and beautiful vitas, is quiet, quiet and welcoming. The patio and outdoor kitchen allow you to do outdoor activities very comfortably. I recommend 100%. Thank you very much Mariel and family!
Guest favourite
Guest house in Mariato
4.96 out of 5 average rating, 80 reviews

Beachfront/Private Full floor Studio in Guesthouse

TealRating, 5 stars1 month ago
We had an absolutely magical stay at this incredible Airbnb! Nestled in the jungle with parrots and monkeys, it was only a short walk to a secluded beach. The sound of the waves from the deck was so peaceful and added to the charm of the place. We loved taking sunset walks on the beach, searching for shells, and simply enjoying the breathtaking views. The pool was a huge hit with our kids. The Airbnb itself was spotless, comfortable, and fully equipped with everything we needed for a wonderful stay. Michael and Lynn were fantastic hosts—super responsive, accommodating, and went above and beyond, even letting us have a late check-out so we could enjoy one last surf session before heading back to Panama City. The location was perfect, just a 15-minute drive to Playa Morrillo for daily surfing and another 15 minutes to the charming town of Torio. We loved this place and can’t wait to visit again one day soon. Highly recommend!
Guest house in Boquete
5 out of 5 average rating, 10 reviews

Vista a Baru

ElliotRating, 5 stars3 months ago
What a magical place! Lily and bob were warm, welcoming, and helpful hosts. We had a couple hiccups along the way and they were extremely responsive in helping us. Their property and the surrounds could not be any more beautiful. We hope to be back soon.

Guest house rentals with a patio

Guest house in La Ermita
4.85 out of 5 average rating, 13 reviews

Piedras Gordas House

JorgeRating, 5 stars1 month ago
Very nice place, pool enough for at least 6-7 people, good size grill to make a barbecue. Quite comfortable bed and very nice baths. The place is still under construction so it is not completely closed, there is little lighting outside (you don't see anything) and the cooler is small for several days, otherwise everything very well, recommended the place no matter what was mentioned. If or if they wear repellent as the listing says.
Guest house in Playa Coronado
4.75 out of 5 average rating, 4 reviews

• Coronado Guesthouse Zuramaya •

AnhaRating, 5 stars1 week ago
This is a wonderful little garden casita just steps from the beach! Its location made for great morning walks. It’s tucked away on a side street but walking distance to a few really good restaurants. Janette was a wonderful host; so kind and helpful. I will definitely be back!
Guest house in Alto del Espino
5 out of 5 average rating, 3 reviews

Tropical Suburban Splendor.

GabyRating, 5 stars16 months ago
Spacious and just what we needed! The apartment is bigger than we expected and it has all your basic needs, including hot water and air conditioning. Emma-Lee was very kind and accommodating.
Guest house in Torio
4.83 out of 5 average rating, 6 reviews

Cozy cabin w/ Queen Bed & ensuite 10 mn from Beach

SereneRating, 5 stars14 months ago
Los Pinos is nestled among pine trees and palm trees as well as many others. Everything is well shaded for a comfortable experience. My cabina was clean, the bed was comfortable. This is a real bed and breakfast, I was treated to eggs cooked to order, served with “hojaldre” a puff pastry, an authentic specialty. The host Mike is personable and a wealth of information about the area
Guest favourite
Guest house in Panama City
4.9 out of 5 average rating, 201 reviews

#1 Personal MiniStudio 9 km Airport @tocumen

ZapataRating, 5 stars1 week ago
I had an excellent experience at the MiniStudio. The place is very cozy, clean and perfect for a stopover close to the airport. What I highlight is Lily's attention: she was always available, very willing to help and make recommendations. I would definitely come back. Thanks for everything Lily!
Guest house in Bocas del Toro
4.8 out of 5 average rating, 30 reviews

Studio w/pool access & near best surf spots.

CassandraRating, 5 stars3 weeks ago
Carolina was a very responsive and friendly host. She greeted me and made me feel right at home. I would stay here again.
Guest house in Torio
4.4 out of 5 average rating, 10 reviews

Olé #1 | Close the beach, restaurants, activities

PabloRating, 5 stars2 weeks ago
I recommend these Cabanas! The price is very affordable and you have a small fully functional and private accommodation, with lots of restaurants and activities around. Communication with the host is frankly very pleasant and responsive. Thanks for the moment:)
Top guest favourite
Guest house in Bocas del Toro
5 out of 5 average rating, 9 reviews

Toucan Bay Lodging & Holistic Services

TessaRating, 5 stars2 months ago
Our stay at Jen and Chris’s Airbnb was pure magic. From the moment we arrived, we were surrounded by breathtaking views and the kind of tranquility that only comes with being right on the water. The casita was thoughtfully designed, with a well-equipped kitchen that made cooking easy and enjoyable. Waking up to the sound of the waves and sipping coffee while watching birds flit through the trees was an absolute dream. The water access here is incredible; calm, clear, and perfect for swimming. We spent so much time in and out of the water, just soaking in the beauty of the place. The kids ran wild together from sunrise to sunset, fully immersed in nature, and we loved seeing them so free and happy. One of the highlights of our trip was the massage I received from Jen. I can confidently say it was one of the best massages of my life. It was intuitive and deeply relaxing. It was exactly what I didn’t even know I needed.

Guest house rentals with a washing machine and dryer

Top guest favourite
Guest house in Panamá Oeste
5 out of 5 average rating, 16 reviews

take a break in a quiet place

SteffiRating, 5 stars1 month ago
Beatriz and her son were super sweet. Everything being clean, very calm. We arrived much later than planned and that wasn't an issue. Beatriz was very patient and friendly. We had to do a lot of online work and were able to do this super well. Laundry was also not an issue. Great facility and super safe. Thanks for everything.
Top guest favourite
Guest house in Boquete District
4.95 out of 5 average rating, 20 reviews

Casa Tropical Boquete Duplex 1 (Tropical House Boquete Duplex 1)

HannahRating, 5 stars1 month ago
We had a great stay! The location felt private and immersed in nature, yet also a very quick drive away from the downtown area. There was a delicious strawberry stand across the street that we enjoyed, and little animals called neque hanging out in the gardens behind the home. Jhayat was kind and accommodating in her communication with us. The place itself felt like a cabin, but with modern amenities like hot showers and a well-equipped kitchen. It was a cute little mountain retreat.
Top guest favourite
Guest house in David
5 out of 5 average rating, 62 reviews

Pool House with Shared Pool Access

VickyRating, 5 stars1 month ago
We recommend this place 1000%. Super nice couple. they gave us lots of tips and good places to visit. The place is spacious and well equipped! We'll go back for sure 🤩
Superhost
Guest house in La Chorrera
5 out of 5 average rating, 3 reviews

A charming spot in La Chorrera

AjotaRating, 5 stars3 months ago
Cozy house type apartment studio inside a main property. The dining room has terracotta tile floors with comfortable and functional furniture. Its areas are illuminated by natural light and decorated with plants. Located in a very quiet area, outside the center.
Guest favourite
Guest house in David
5 out of 5 average rating, 7 reviews

Cozy, quiet and great location!

BlaneRating, 5 stars11 months ago
Staying here was an outstanding experience in more ways than one. This is a good location for exploring other parts of Panama. Look up "Villa del Carmen, David, Panama" on Google Maps to get an idea. Tranquil is a good way to describe the area also. Apt. Isn't big, but is plenty good for 1 or 2 people. Kitchen & sitting areas are outside, with everything you need. If it gets too hot in the afternoon, just take a little siesta inside & you'll be fine. Very relaxing! Lina was an excellent host, & I had the pleasure of spending time with her. The apt. itself is behind the home of a nice, sweet, kind, helpful, generous woman named Amarilis. Get to know her! Amarilis turned a good experience into a great one! We had many good conversations (using Google Translate), she was patient with my lousy Spanish & I enjoyed her company very much. She & Lina helped make my decision to move to Panama an easy one, & I look forward to seeing them both again. Wish I could write more! I highly recommend!
Guest favourite
Guest house in Los Naranjos
4.71 out of 5 average rating, 70 reviews

Alicia's Cabins 1

VeroniqueRating, 5 stars1 month ago
Clean and nice place, fits described bedrooms. Ezequiel was very friendly and helpful. Well placed, a bit further from Boquete but still close and close to the Lost falls that was a great hike. Washington machine was not in the unit but easy to wash clothes asking Ezequiel. Beds were comfortable.
Superhost
Guest house in La Concepcion
4.17 out of 5 average rating, 6 reviews

New tropical guesthouse

MariaRating, 5 stars2 months ago
A very comfortable casita with well functioning A/C - needed as David temp is HOT. Great kitchen space and appliances . River/creek on the property is perfect for swimming & bird / butterfly watching. Donald is a very helpful, interesting host , ready to solve any issues that may come up. I enjoyed my stay thoroughly & would recommend Donald's guesthouse as a good base for exploring nearby Vulcan, Boquete and easy access to the Costa Rica Border.
Superhost
Guest house in Panamá
4.38 out of 5 average rating, 13 reviews

Convenient, centrally located suite with parking

GeorgeRating, 5 stars8 months ago
excellent in everything, I felt at home, complete accommodation more complete than my house, haha, excellent host. i'll be back for sure.

Destinations to explore